Anti-NR4A1 Antibody (Clone#ABGF-14)

50μl/1280 100μl/2180 150μl/2800

Early response protein NAK1; GFRP1; HMR; N10; NAK 1; NAK1; NGFIB; NR4A1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST 59; Testicular receptor 3; TR3

Monoclonal

human, mouse, rat

WB

NR4A1

ABGF-14

Rabbit

IgG

A synthesized peptide derived from human NUR77

64 kDa

67 kDa

500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.

Affinity-chromatography

500 ug/ml

Liquid

12 months from date of receipt，-20℃ as supplied.

NR4A1(NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1), also called NAK1, GFRP1, TR3, NUR77 or NGFIB, is a protein that in humans is encoded by the NR4A1 gene, which is also a member of the Nur nuclear receptor family of intracellular transcription factors. The NR4A1 gene is mapped on 12q13.13. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. It plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells. Nr4a1 was overexpressed in Wnt1 -transformed mouse mammary cells. Nr4a1 was also induced by lithium, a Wnt1 mimic, and the Nr4a1 promoter was activated by lithium and beta-catenin, a Wnt1 downstream effector. In contrast, human NR4A1 was not upregulated by beta-catenin, indicating that this gene is regulated differently in human and mouse cells. Adenoviral expression of Nr4a1 induced genes involved in gluconeogenesis, stimulated glucose production both in vitro and in vivo, and raised blood glucose levels.

P22736  

NR4A1 Antibody (Clone#ABGF-14) (Boster Biological Technology, Wuhan, China. Catalog#BM5158)

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

Nuclear receptor subfamily 4 group A member 1

Western blot (WB):

1:500-2000