Anti-Alpha E-Catenin/CTNNA1 Antibody (Clone#FBO-3)

Rabbit monoclonal antibody

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筛选器： All WB IHC ICC/IF IP FCM

BM4486

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期：现货

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Western blot analysis of anti-CTNNA1 antibody (BM4486). The sample well of each lane was loaded with 30 ug of sample under reducing conditions.
Lane 1: human Hela whole cell lysates,
Lane 2: human 293T whole cell lysates,
Lane 3: human U-87MG whole cell lysates,
Lane 4: rat C6 whole cell lysates,
Lane 5: mouse brain tissue lysates.
After electrophoresis, proteins were transferred to a membrane. Then the membrane was incubated with rabbit anti-CTNNA1 antigen affinity purified monoclonal antibody (BM4486) at a dilution of 1:1000 and probed with a goat anti-rabbit IgG-HRP secondary antibody (Catalog # BA1054). The signal is developed using ECL Plus Western Blotting Substrate (Catalog # AR1197). A specific band was detected for CTNNA1 at approximately 100 kDa. The expected band size for CTNNA1 is at 100 kDa.
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Immunohistochemical analysis of paraffin-embedded human lung cancer, using Catenin alpha 1 Antibody.
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产品名称

Anti-Alpha E-Catenin/CTNNA1 Antibody (Clone#FBO-3)

规格/价格

50μl/1280 100μl/2180 150μl/2800

指标别称

alpha catenin; Alpha E catenin; Alpha E-Catenin; Cadherin associated protein; CAP102; Catenin alpha 1; CTNNA1; α-catenin; α-E-catenin; αE-catenin

产品类型

Monoclonal

检验物种

human, mouse, rat

应用范围

WB, IHC, ICC/IF, IP, FCM

基因名称

CTNNA1

克隆号

FBO-3

宿主

Rabbit

抗体亚型

IgG

免疫原

A synthesized peptide derived from human Catenin alpha 1

计算分子量

100 kDa

实际分子量

100 kDa

成分

500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.

纯化方式

Affinity-chromatography

浓度

500 ug/ml

产品形态

Liquid

保存条件

12 months from date of receipt，-20℃ as supplied.

背景资料

CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.

Uniprot ID

P35221

文献引用格式

Alpha E-Catenin/CTNNA1 Antibody (Clone#FBO-3) (Boster Biological Technology, Wuhan, China. Catalog#BM4486)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

基因名全称

Catenin alpha-1

实验方案>

实验步骤

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