产品名称
Anti-P27/KIP1/CDKN1B Antibody (Clone#DCS-72)
规格/价格
50μl/1280 100μl/2180 150μl/2800
指标别称
CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27; P27; KIP1; P27KIP1
免疫原
recombinant rodent p27Kip1 protein.
成分
200ug/ml antibody with PBS ，0.02% NaN3 , 1mg BSA and 50% glycerol.
保存条件
12 months from date of receipt，-20℃ as supplied.
背景资料
P27(kip1), also known as cyclin dependent kinase inhibitor 1B(CDKN1B), is a major target of AFX-like forkhead proteins. CDKN1B(p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper. Phosphorylation leads to the ubiquitination and degradation of CDKN1B. P27(kip1) mapped to 12p13. An increase in p27 causes proliferating cells to exit from the cell cycle, and a decrease in p27 is necessary for quiescent cells to resume division. Abnormally low amounts of p27 are associated with pathological states of excessive cell proliferation, especially cancers. Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells.
文献引用格式
P27/KIP1/CDKN1B Antibody (Clone#DCS-72) (Boster Biological Technology, Wuhan, China. Catalog#BM1594)
应用释义
WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;
推荐配套的二抗和检测试剂
Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and ICC.
基因名全称
cyclin-dependent kinase inhibitor 1B(p27, Kip1)
蛋白名全称
Cyclin-dependent kinase inhibitor 1B
推荐稀释比
| Western blot (WB): | 1:500-2000 |
| Immunocytochemistry/Immunofluorescence (ICC/IF): | 1:50-400 |
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