产品名称
Anti-BTK (Phospho-Y223) Antibody (Clone#ECD-2)
规格/价格
50μl/1180 100μl/1960 150μl/2780
指标别称
AGMX1; AT; ATK; B cell progenitor kinase; BPK; Bruton tyrosine kinase; BTK; IMD1; PSCTK1; Tyrosine protein kinase BTK; XLA
免疫原
A synthesized peptide derived from human Phospho-BTK (Y223)
成分
500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.
纯化方式
Affinity-chromatography
保存条件
12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
BTK, also known as Bruton's tyrosine kinase, is an enzyme that in humans is encoded by the BTK gene. It is mapped to Xq22.1. BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. BTK contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces BTK to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling. This gene also regulates both TLR9 activation and expression in B lymphocytes and is necessary for inhibitory cytokine expression.
文献引用格式
BTK (Phospho-Y223) Antibody (Clone#ECD-2) (Boster Biological Technology, Wuhan, China. Catalog#BM4397)
应用释义
WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光; ICC－免疫细胞化学; IHC-F- 冰冻切片免疫组化; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;
基因名全称
Tyrosine-protein kinase BTK
推荐稀释比
| Western blot (WB): | 1:500-2000 |
| ImmunoPrecipitation (IP): | 1:20 |
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