Anti-NRF2/NFE2L2 Antibody (Clone#OTI8A10)

50μl/1280 100μl/2180 150μl/2800

HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; NRF2; NRF2; NFE2L2

Monoclonal

human

WB

NFE2L2

OTI8A10

Mouse

IgG2a

Human recombinant protein fragment corresponding to amino acids 330-605 of human NFE2L2 (NP_006155) produced in E.coli.

68 kDa

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

500 ug/ml

Liquid

Stable for 12 months from date of receipt. Store at -20°C as received.

NFE2L2(nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-RELATED TRANSCRIPTION FACTOR 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas(G12D) and BRaf(V619E), and in human pancreatic cancer.

Q16236  

NRF2/NFE2L2 Antibody (Clone#OTI8A10) (Boster Biological Technology, Wuhan, China. Catalog#M00078-1)

WB- 蛋白质免疫印迹法,IHC- 免疫组织化学法,ICC/IF-免疫细胞荧光,ICC－免疫细胞化学,IHC-F- 冰冻切片免疫组化,FCM-流式细胞术,ELISA-酶联免疫吸附测定,IP-免疫沉淀法 ,IF-免疫组织荧光法,ChIP-染色质免疫沉淀法

nuclear factor, erythroid 2 like 2

Nuclear factor erythroid 2-related factor 2

Western blot (WB):

1:2000