产品名称
Anti-CDC6 Antibody (Clone#DCS-180)
规格/价格
50μl/1280 100μl/2180 150μl/2800
指标别称
Cdc18 related protein; CDC18L; CDC6; CDC6 related protein; HsCDC18; HsCDC6; p62(cdc6)
免疫原
Recombinant human Cdc6.
成分
200ug/ml antibody with PBS ，0.02% NaN3 , 1mg BSA and 50% glycerol.
保存条件
12 months from date of receipt，-20℃ as supplied.
背景资料
In yeasts, Cdc6(Saccharomyces cerevisiae) and Cdc18(Schizosaccharomyces pombe) associate with the origin recognition complex(ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al.(1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.
文献引用格式
CDC6 Antibody (Clone#DCS-180) (Boster Biological Technology, Wuhan, China. Catalog#BM1579)
应用释义
WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;
推荐配套的二抗和检测试剂
Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and ICC.
基因名全称
cell division cycle 6 homolog(S. cerevisiae)
蛋白名全称
Cell division control protein 6 homolog
推荐稀释比
| Western blot (WB): | 1:500-2000 |
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