Anti-P glycoprotein/ABCB1 Antibody (Clone#OTI3C8)

Mouse monoclonal antibody

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筛选器： All IHC

M00049-4

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期： 5-7天

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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ABCB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, M00049-4)
all(1)

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产品名称

Anti-P glycoprotein/ABCB1 Antibody (Clone#OTI3C8)

规格/价格

50μl/1280 100μl/2180 150μl/2800

指标别称

ABC20; ABCB1; CD243; CLCS; GP170; MDR1; Multidrug resistance protein 1; P glycoprotein; P glycoprotein 1; P-gp

产品类型

Monoclonal

检验物种

human, mouse, rat

应用范围

IHC

基因名称

ABCB1

克隆号

OTI3C8

宿主

Mouse

抗体亚型

IgG1

免疫原

Human recombinant protein fragment corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) produced in SF9 cell.

成分

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

纯化方式

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

浓度

500 ug/ml

产品形态

Liquid

保存条件

Stable for 12 months from date of receipt. Store at -20°C as received.

背景资料

P-GP, also called ABCB1 or PGY1, is a glycoprotein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily. It is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent drug efflux pump with broad substrate specificity. P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

Uniprot ID

P08183

文献引用格式

P glycoprotein/ABCB1 Antibody (Clone#OTI3C8) (Boster Biological Technology, Wuhan, China. Catalog#M00049-4)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

Anti-P glycoprotein/ABCB1 Antibody (Clone#OTI3C8)

筛选器： All IHC

M00049-4

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Anti-P glycoprotein/ABCB1 Antibody (Clone#OTI3C8)

筛选器： All IHC

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