Anti-KIM-1/HAVCR1 Antibody

Rabbit polyclonal antibody

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筛选器： All WB ELISA(Cap)

A01306

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期：现货

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Western blot analysis of KIM-1/HAVCR1 using anti-KIM-1/HAVCR1 antibody (A01306).
Lane 1: recombinant human TIM1 protein 1ng.
After electrophoresis, proteins were transferred to a membrane. Then the membrane was incubated with rabbit anti-KIM-1/HAVCR1 antigen affinity purified polyclonal antibody (A01306) at a dilution of 1:1000 and probed with a goat anti-rabbit IgG-HRP secondary antibody (Catalog # BA1054). The signal is developed using ECL Plus Western Blotting Substrate (Catalog # AR1197). A specific band was detected for KIM-1/HAVCR1 at approximately 39,50 kDa.
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产品名称

Anti-KIM-1/HAVCR1 Antibody

规格/价格

50μl/1280 100μl/2180 150μl/2800

指标别称

hepatitis A virus cellular receptor 1; CD365; HAVCR; HAVCR-1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD-1; TIMD1; HAVCR1

产品类型

Polyclonal

检验物种

human

应用范围

WB, ELISA(Cap)

基因名称

HAVCR1

宿主

Rabbit

抗体亚型

IgG

免疫原

E. coli-derived human TIM 1 recombinant protein (Position: Q58-K289).

计算分子量

39 kDa

实际分子量

39,50 kDa

成分

500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.

纯化方式

Immunogen affinity purified.

浓度

500 ug/ml

产品形态

Liquid

保存条件

12 months from date of receipt，-20℃ as supplied.

背景资料

KIM1(KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 are conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.

Uniprot ID

Q96D42

RRID

AB_3081412

文献引用格式

KIM-1/HAVCR1 Antibody (Boster Biological Technology, Wuhan, China. Catalog#A01306)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

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