Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody

Rabbit polyclonal antibody

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筛选器： All IHC

BA1353-1

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期：现货

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IHC analysis of PI3 Kinase p110 Alpha/PIK3CA using anti-PI3 Kinase p110 Alpha/PIK3CA antibody (BA1353-1).
PI3 Kinase p110 Alpha/PIK3CA was detected in a paraffin-embedded section of human breast cancer tissue. Biotinylated goat anti-rabbit IgG was used as secondary antibody. The tissue section was incubated with rabbit anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (BA1353-1) at a dilution of 1:200 and developed using Strepavidin-Biotin-Complex (SABC) (Catalog # SA1022) with DAB (Catalog # AR1027) as the chromogen.
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产品名称

Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody

规格/价格

50μl/1280 100μl/2180 150μl/2800

指标别称

p110 alpha; PI3 kinase subunit alpha; PI3K; PI3K alpha; PI3K p110(alpha); PIK3CA; PtdIns 3 kinase subunit alpha

产品类型

Polyclonal

检验物种

human, mouse, rat, rabbit

应用范围

IHC

基因名称

PIK3CA

宿主

Rabbit

抗体亚型

IgG

免疫原

E.coli-derived human PIK3CA recombinant protein (Position: H936-N1068). Human PIK3CA shares 98% amino acid (aa) sequence identity with mouse PIK3CA.

成分

500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.

纯化方式

Immunogen affinity purified.

浓度

500 ug/ml

产品形态

Liquid

保存条件

12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.

背景资料

Phosphatidylinositol-4,5-bisphosphate 3-kinase, also called PIK3CA, is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. PIK3CA gene is mapped to 3q26.32. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P andPtdIns(4,5)P2. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. It has been found to be oncogenic and has been implicated in cervical cancers. PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy. In addition to that, the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer, indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.

Uniprot ID

P42336

文献引用格式

PI3 Kinase p110 Alpha/PIK3CA Antibody (Boster Biological Technology, Wuhan, China. Catalog#BA1353-1)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

基因名全称

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

蛋白名全称

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

实验方案>

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