产品名称
Anti-BTK (Phospho-Y223) Antibody (Clone#ECD-2)
规格/价格
50μl/1280 100μl/2180 150μl/2800
指标别称
AGMX1; AT; ATK; B cell progenitor kinase; BPK; Bruton tyrosine kinase; BTK; IMD1; PSCTK1; Tyrosine protein kinase BTK; XLA
免疫原
A synthesized peptide derived from human Phospho-BTK (Y223)
成分
500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.
纯化方式
Affinity-chromatography
保存条件
12 months from date of receipt，-20℃ as supplied.
背景资料
BTK, also known as Bruton's tyrosine kinase, is an enzyme that in humans is encoded by the BTK gene. It is mapped to Xq22.1. BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. BTK contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces BTK to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling. This gene also regulates both TLR9 activation and expression in B lymphocytes and is necessary for inhibitory cytokine expression.
文献引用格式
BTK (Phospho-Y223) Antibody (Clone#ECD-2) (Boster Biological Technology, Wuhan, China. Catalog#BM4397)
应用释义
WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;
基因名全称
Tyrosine-protein kinase BTK
推荐稀释比
| Western blot (WB): | 1:500-2000 |
| ImmunoPrecipitation (IP): | 1:20 |
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