Anti-PTBP1 Antibody (Clone#AFEO-16)

50μl/1280 100μl/2180 150μl/2800

HNRNP I; HNRNPI; HNRPI; pPTB; PTB; PTB 1; PTB T; PTB2; PTB3; PTB4; PTBP1

Monoclonal

human, mouse, rat

WB, IHC, ICC/IF

PTBP1

AFEO-16

Rabbit

IgG

A synthesized peptide derived from human PTBP1

57 kDa

500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.

Affinity-chromatography

500 ug/ml

Liquid

12 months from date of receipt，-20℃ as supplied.

Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It is mapped to 19p13.3. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

P26599  

PTBP1 Antibody (Clone#AFEO-16) (Boster Biological Technology, Wuhan, China. Catalog#BM5722)

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

Western blot (WB):	1:500-2000
Immunohistochemistry (IHC):	1:50-200
Immunocytochemistry/Immunofluorescence (ICC/IF):	1:50-200