产品名称
Anti-UPF1 Antibody (Clone#19U80)
规格/价格
50μl/1280 100μl/2180 150μl/2800
指标别称
ATP dependent helicase RENT1; FLJ43809; FLJ46894; HUPF1; KIAA0221; NORF1; pNORF1; RENT1; UPF1
应用范围
WB, IHC, ICC/IF, IP, FCM
免疫原
A synthesized peptide derived from human RENT1 / hUPF1
成分
500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.
纯化方式
Affinity-chromatography
保存条件
12 months from date of receipt，-20℃ as supplied.
背景资料
Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. And this protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
文献引用格式
UPF1 Antibody (Clone#19U80) (Boster Biological Technology, Wuhan, China. Catalog#M00900-2)
应用释义
WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;
基因名全称
UPF1 regulator of nonsense transcripts homolog (yeast)
蛋白名全称
Regulator of nonsense transcripts 1
推荐稀释比
| Western blot (WB): | 1:1000-5000 |
| Immunohistochemistry (IHC): | 1:50-200 |
| Immunocytochemistry/Immunofluorescence (ICC/IF): | 1:50-200 |
| ImmunoPrecipitation (IP): | 1:50 |
| Flow Cytometry (FCM): | 1:50 |
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