Anti-TGFBR1 Antibody

Rabbit polyclonal antibody

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筛选器： All WB

PB0872

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期：现货

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Western blot analysis of TGFBR1 using anti-TGFBR1 antibody (PB0872). The sample well of each lane was loaded with 30 ug of sample under reducing conditions.
Lane 1: human Hela whole cell lysates,
Lane 2: human SW579 whole cell lysates.
After electrophoresis, proteins were transferred to a membrane. Then the membrane was incubated with rabbit anti-TGFBR1 antigen affinity purified polyclonal antibody (PB0872) at a dilution of 1:1000 and probed with a goat anti-rabbit IgG-HRP secondary antibody (Catalog # BA1054). The signal is developed using ECL Plus Western Blotting Substrate (Catalog # AR1197). A specific band was detected for TGFBR1 at approximately 56 kDa. The expected band size for TGFBR1 is at 56 kDa.
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产品简介>

产品名称

Anti-TGFBR1 Antibody

规格/价格

50μl/1280 100μl/2180 150μl/2800

指标别称

transforming growth factor beta receptor 1; AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TBR-i; TBRI; TGFR-1; tbetaR-I; TGFBR1

产品类型

Polyclonal

检验物种

human, mouse, rat

应用范围

基因名称

TGFBR1

宿主

Rabbit

抗体亚型

IgG

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human TGFBR1 identical to the related mouse and rat sequences.

计算分子量

56 kDa

实际分子量

56 kDa

成分

500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.

纯化方式

Immunogen affinity purified.

浓度

500 ug/ml

产品形态

Liquid

保存条件

12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.

背景资料

Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss (1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.

Uniprot ID

P36897

文献引用格式

TGFBR1 Antibody (Boster Biological Technology, Wuhan, China. Catalog#PB0872)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

基因名全称

transforming growth factor, beta receptor 1

蛋白名全称

TGF-beta receptor type-1

实验方案>

实验步骤

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